Vol.52 No.11 November 2004

Survey of Candida species in Yamanashi

Hiromi Fukasawa¹⁾, Takeshi Endo²⁾, Takashi Uchida²⁾, Mie Mikami³⁾, Toshiko Ohya⁴⁾, Seitaro Inoue⁵⁾, Hiroko Yamamoto⁶⁾ and Yukio Ozaki⁷⁾

¹⁾Bacteriological Examination Room, Yamanashi Kosei Hospital, 860 Ochiai, Yamanashi, Japan
²⁾Clinical Laboratory, University of Yamanashi Hospital
³⁾Department of Clinical Laboratory, Kofu Municipal Hospital
⁴⁾Department of Inspection, Yamanashi Prefectural Central Hospital
⁵⁾Bacteriological Examination Room, Yamanashi Hospital of Social Insurance
⁶⁾Department of Inspection, Kofu-Kyoritsu Hospital
⁷⁾Clinical and Laboratory Medicine, Faculty of Medicine, University of Yamanashi

Abstract

During the 6 months between April and September 2003, we monitored the frequency of Candida spp. isolation and resistance at 6 facilities in Yamanashi.
Samples numbered 8,496, and Candida spp. was predominantly isolated from 608 isolates (7.2%). By species, Candida albicans was most frequently isolated, accounting for 67.3% of all Candida isolates. The second and third most frequent isolates were Candida glabrata (16.0%; 97 isolates) and Candida tropicalis (14.0%; 85 isolates). Candida parapsilosis accounted for 1.6% (10 isolates).
Frequently isolated C. albicans, C. glabrata, and C. tropicalis, numbering 420 isolates, were subjected to susceptibility testing, and 1 μ g/mL of amphotericin B and 0.13 μ g/mL of micafungin inhibited the growth of all isolates tested. The MIC of fluconazole distributed from 0.13 μ g/mL to > 128 μ g/mL, and 2.6% of isolates were susceptible dose-dependently, while 2.1% were resistant.
Analysis of multicenter survey results may thus help in selecting therapeutic agents for deep mycosis, which is difficult to diagnose and treat.

Key word

surveillance, Candida spp., drug-resistance, fluconazole, micafungin

Received

August 17, 2004

Accepted

September 15, 2004

Jpn. J. Chemother. 52 (11): 654-659, 2004