Vol.54 No.2 March 2006
In vitro combination effect of glycopeptides and β-lactams against methicillin-resistant Staphylococcus aureus
1)Department of Pediatrics, General Ota Hospital, Society of Health Insurance of Fuji Heavy Industries Ltd.,
29-5 Hachimancho, Ota, Gunma, Japan
2)Department of Pharmacy, General Ota Hospital, Society of Health Insurance of Fuji Heavy Industries Ltd.
3)Department of Pediatrics, National Hospital Organization Tokyo Medical Center
4)Department of Pediatrics, St. Marianna University School of Medicine, Yokohama City Seibu Hospital
5)Department of Infectious Diseases, Kitasato University School of Medicine
Abstract
We investigated the combination effect of teicoplanin (TEIC) or vancomycin (VCM) and 6 β-lactams in vitro using 49 strains of methicillin-resistant Staphylococcus aureus (MRSA) isolated from neonates who were admitted to the newborn intensive care unit. We combined TEIC with imipenem (IPM), meropenem (MEPM), panipenem (PAPM), cefpirome (CPR), flomoxef (FMOX), or sulbactam (SBT) /ampicillin (ABPC). Synergistic effects were noted in 16 to 48 strains. In particular, the combinations of TEIC and IPM, MEPM, PAPM, or FMOX showed synergistic effects in many strains. Furthermore, 3 strains did not respond to the combination of TEIC and CPR; however, none of the strains exhibited antagonism. Combination with VCM and the above β-lactams produced synergistic effects in 1 to 32 strains. No changes were seen in 1 to 17 strains, and 2 to 6 strains exhibited antagonism. These results suggest that, when combined with the β-lactams tested, TEIC exhibits more potent synergistic effects than VCM.
Key word
MRSA, teicoplanin, vancomycin, β-lactam, combination effect
Received
October 25, 2005
Accepted
December 12, 2005
Jpn. J. Chemother. 54 (2): 95-101, 2006
