Vol.55 No.6 November 2007

Study of antibacterial activity and optimized dosing of Carbapenems against Pseudomonas aeruginosa isolated from blood culture

Yoshimi Higurashi, Ito Kobayashi, Kyoji Moriya and Kazuhiko Koike

Department of Infection Control and Prevention, University of Tokyo Hospital, 7-3-1 Hongou, Bunkyo-ku, Tokyo, Japan

Abstract

Antibacterial activity against 67 Pseudomonas aeruginosa isolates from blood culture from 2000 to 2004 were studied by measuring the minimum inhibitory concentration(MIC) and compared to previous data. Optimized carbapenem dosing was designed using Monte Carlo simulation.
The MIC₉₀ of meropenem(MEPM), biapenem(BIPM), imipenem/cilastatin(IPM/CS) and panipenem/betamipron (PAPM/BP) was 16 μg/mL, 16 μg/mL, 32 μg/mL, and 64 μg/mL.
The MIC₉₀ of ciprofloxacin(CPFX) was 2 μg/mL, the lowest MIC in antibiotics tested. The number of isolates producing class B β-lactamase was 1(1.5%) and multidrug-resistant organisms was 3(4.5%).
Treatment with MEPM 0.5 g×3/day conferred the highest probability(59.3%) of target attainment for target pharmacodynamic exposures(time above MIC was 50%). In conclusion, MEPM(0.5 g×3/day) may be an effective regimen for empiric therapy against bacteremia with P. aeruginosa.

Key word

blood culture, pharmacokinetic/pharmacodynamic, carbapenem, Pseudomonas aeruginosa

Received

February 15, 2007

Accepted

August 6, 2007

Jpn. J. Chemother. 55 (6): 435-440, 2007