Vol.56 No.S-1 April 2008

Pharmacokinetic profiles of sitafloxacin in elderly volunteers

Hisakuni Sekino

Sekino Hospital, 3-28-3 Ikebukuro, Toshima-ku, Tokyo, Japan

Abstract

The effect of aging on the pharmacokinetic profile of sitafloxacin(STFX) was investigated by comparing 5 elderly (>65 years) and 6 non elderly (=20 to <40 years) male volunteers.
Following a single oral administration of 100 mg of STFX, elderly volunteers showed delayed t_max, prolonged t_1/2, decreased renal clearance, and increased AUC_0-24h compared to non elderly volunteers. No notable differences were observed in cumulative urinary excretion (0-48 h). No significant adverse drug reactions were observed in either groups.

Key word

sitafloxacin, elderly, pharmacokinetics, fluoroquinolone

Received

November 2, 2007

Accepted

December 28, 2007

Jpn. J. Chemother. 56 (S-1): 18-20, 2008