Vol.56 No.S-1 April 2008
Pharmacokinetics of sitafloxacin (DU-6859a) in healthy volunteers
Hamamatsu Institute of Clinical Pharmacology and Therapeutics, 40-3 Sukenobu, Naka-ku, Hamamatsu, Shizuoka, Japan
Abstract
We studied the pharmacokinetics of sitafloxacin(STFX) in healthy male volunteers given single oral doses 25 mg, 50 mg, 100 mg (fasting and non fasting state), or 200 mg. Non compartmental analysis was used to calculate pharmacokinetic parameters of STFX. Cmax of 0.29, 0.51, 1.00, 0.88, and 1.86 of serum appeared within 1 to 2 h after administration. After Cmax was reached, serum drug levels decreased with elimination half-lives of 5 to 6 h. Cmax and AUC0-inf increased in a dose proportional manner. We found a good linear correlation between administered doses and resulting Cmax and AUC0-inf. Food intake did not significantly influence STFX pharmacokinetics.
Key word
sitafloxacin, pharmacokinetics, fluoroquinolone, phase I study
Received
October 5, 2007
Accepted
December 13, 2007
Jpn. J. Chemother. 56 (S-1): 154-155, 2008
