Vol.57 No.S-1 March 2009
Effect of diet including ice cream and pudding on tebipenem pivoxil fine granules pharmacokinetics in healthy male volunteers
1)Hamamatsu Institute of Clinical Pharmacology & Therapeutics, 40-3 Sukenobu, Naka-ku, Hamamatsu, Shizuoka, Japan
2)Clinical Research Department, Meiji Seika Kaisha, LTD.
Abstract
We assessed the pharmacokinetics of tebipenem pivoxil(TBPM-PI) fine granules, an oral carbapenem antibiotic, and TBPM prodrug, in healthy male volunteers during fasting and nonfasting. We also studied the effect of dairy products such as ice cream and pudding, which are likely to be consumed by pediatric patients, instead of meals on TBPM-PI fine granules pharmacokinetics in healthy male volunteers.
We assessed pharmacokinetics at 200 mg (potency) during fasting and after a meal, ice cream, or pudding. The Cmax and AUC0-∞ of TBPM after a meal, ice cream, or pudding were 40-60 and 80% of those in the fasting state, and urinary excretion was comparable between fasting and nonfasting.
In conclusion, TBPM-PI absorption rate was lower during nonfasting after the administration of TBPM-PI fine granules. Eating a meal, ice cream, or pudding influenced the amount of absorption only negligibly, if at all.
Key word
tebipenem pivoxil, pharmacokinetics, food-drug interaction, ice cream, custard pudding
Received
October 15, 2008
Accepted
December 12, 2008
Jpn. J. Chemother. 57 (S-1): 95-98, 2009
