Vol.59 No.3 May 2011

Drug-susceptibilities of Neisseria gonorrhoeae strains isolated from male patients with gonococcal urethritis against antimicrobial agents -Comparisons from 2006 to 2010-

Katsuhisa Endo¹⁾, Shoichi Onodera²⁾, Hiroshi Kiyota³⁾, Hiroo Suzuki⁴⁾, Takahide Hosobe⁵⁾, Tatehito Naruoka⁶⁾ and Kunitaro Sanuki¹⁾

¹⁾Department of Urology, JR Tokyo General Hospital, 2-1-3 Yoyogi, Shibuya-ku, Tokyo, Japan
²⁾Fuji City Fuji Central Hospital
³⁾Department of Urology, The Jikei University Aoto Hospital
⁴⁾Department of Urology, Kosei Hospital
⁵⁾Hosobe Clinic
⁶⁾Department of Urology, The Jikei University Third Hospital

Abstract

We investigated the drug susceptibilities (to penicillin G(PCG), clavulanic acid/amoxicillin(CVA/AMPC), cefixime(CFIX), cefteram(CFTM), ceftriaxone(CTRX), cefodizime(CDZM), aztreonam(AZT), spectinomycin(SPCM), tetracycline(TC), azithromycin(AZM) and levofloxacin(LVFX)) of 156 Neisseria gonorrhoeae strains (2006: 47 strains; 2007: 23 strains; 2008: 18 strains; 2009: 38 strains; 2010: 30 strains), which were isolated from male urethritis patients at The Jikei University School of Medicine and related hospitals of the Metropolitan Area between 2005 and 2010. β-lactamase production by the strains was also examined. The antimicrobial activities of PCG, CVA/AMPC, CFTM, AZT, TC and LVFX were consistently low during these 5 years. On the other hand, while the MIC₅₀ and MIC₉₀ of CFIX were 0.06 μg/mL and 0.12 μg/mL, respectively in 2006, the values [both MIC₅₀ and MIC₉₀] increased to 0.25 μg/mL in 2010, indicating the acquisition of CFIX-resistance. The MIC₅₀ values of CTRX and CDZM were close to the MIC₉₀ values, suggesting the potential emergence of CTRX/CDZM-resistant strains of N. gonorrhoeae in the near future.

Key word

Neisseria gonorrhoeae, male urethritis, drug susceptibility

Received

March 24, 2011

Accepted

April 7, 2011

Jpn. J. Chemother. 59 (3): 308-312, 2011