Vol.67 No.5 September 2019
Infectious disease and infection control in the era of the AMR action plan-Epidemiological molecular characterization and clinical presentation of CA-MRSA in Japan-
Department of Microbiology and Infectious Diseases, Toho University School of Medicine, 5-21-16 Omori-nishi, Ota-ku, Tokyo, Japan
Abstract
MRSA is a multidrug resistant organism that is frequently encountered in the healthcare setting (HA-MRSA). Increasing attention paid to the concept of infection control and prevention has resulted in a reduction in the rate of detection of MRSA around the world since the early 2000s. However, community-associated MRSA (CA-MRSA) infections that can occur in otherwise healthy individuals, including children, appeared in the 1990s. Furthermore, since the mid-2000s, MRSA infection associated with livestock exposure (LA-MRSA) has also been reported. Thus, MRSA has become a threat in a variety of environments. In Japan, the detection frequency of MRSA is still high: about 49% of all Staphylococcus aureus clinical isolates were methicillin-resistant in 2014. In April 2016, the antimicrobial resistance (AMR) action plan was prepared due to the fear of spread of multidrug resistant organisms around the world. One of the objectives of preparation of this document was to reduce the incidence of methicillin resistance of S. aureus to 20% or less by 2020. In Japan, the incidence of methicillin resistance of S. aureus remains higher than that in other developed countries, and the detection rate of CA-MRSA has been increasing. A new approach or a new system is needed to accelerate the lowering of the incidence at a rate of at least approximately 5% per year.
Key word
national action plan on antimicrobial resistance, MRSA, infection control
Received
October 10, 2018
Accepted
March 8, 2019
Jpn. J. Chemother. 67 (5): 567-576, 2019
