Vol.70 No.5 September 2022
Vancomycin removal ratio in patients on hemodialysis
1)Department of Pharmacy, Toranomon Hospital, 2-2-2 Toranomon, Minato-ku, Tokyo, Japan
2)Department of Infectious Diseases, Toranomon Hospital
3)Department of Nephrology Center, Toranomon Hospital
Abstract
The aim of this study was to determine the vancomycin (VCM) removal ratio in patients on hemodialysis (HD). Data of 19 patients (14 men, 5 women) on HD who were treated with VCM between October 2010 and September 2011 at Toranomon Hospital (Tokyo, Japan) were retrospectively evaluated. The median age was 67.6 (range, 43-87) years. The HD conditions were as follows: membrane area, 1.39 m2; blood and dialysate flow rate, 168.9 mL/min; and dialysis time, 3.7 h. The VCM removal ratio was defined as follows: VCM removal ratio (%) = [(Pre-HD serum concentration)-(4 h post-HD serum concentration)]/(Pre-HD serum concentration)×100. In the 19 patients, the mean VCM removal ratio was 22.9%±8.2% (range, 8.8-42.6%). The ratio was 21.6%±7.2% (range, 8.8-32.7%) in the 16 patients treated with a type IV dialyzer (β2-microglobulin clearance, 50-70 mL/min) classified in Japan, and 29.7%±11.7% (range, 19.7-42.6%) in 3 patients treated with a type V dialyzer (β2-microglobulin clearance ≥70 mL/min). In conclusion, our study showed that the VCM removal ratio varied according to type of dialyzer used and the dialysis vintage. Therefore, the administration should be designed individually in consideration of the differences in the dialyzer and dialysis conditions.
Key word
vancomycin, hemodialysis
Received
December 7, 2021
Accepted
June 10, 2022
Jpn. J. Chemother. 70 (5): 396-401, 2022
