Vol.73 No.6 November 2025

Sensitivity of carbapenem-resistant gram-negative rods isolated at Japanese Red Cross Okayama Hospital to cefiderocol

Takumi Miyamoto¹⁾, Mai Kagawa¹⁾, Kanako Kawachi¹⁾, Tomoyuki Ohyama¹⁾, Masahiro Oda¹⁾, Nobuyuki Hanafusa²⁾, Ayako Koike²⁾, Shinobu Hosokawa³⁾, Satoru Oku⁴⁾, Hideki Mori²⁾ and Akihiro Bessho³⁾

¹⁾Department of Clinical Laboratory, Japanese Red Cross Okayama Hospital, 2-1-1 Aoe, Kita-ku, Okayama City, Okayama Prefecture, Japan
²⁾Department of Pharmacy, Japanese Red Cross Okayama Hospital
³⁾Department of Respiratory Medicine, Japanese Red Cross Okayama Hospital
⁴⁾Department of Anesthesiology, Japanese Red Cross Okayama Hospital

Abstract

Cefiderocol (CFDC) is a new β-lactam antibiotic with broad antimicrobial activity against multidrug-resistant gram-negative rods, including carbapenem-resistant Enterobacterales (CRE).
In this study, we determined the sensitivity of carbapenem-resistant gram-negative rods isolated at our hospital to CFDC.
A total of 56 carbapenemase-producing Enterobacterales (CPE), 5 non-carbapenemase-producing Enterobacterales (non-CPE), 19 carbapenem-resistant Pseudomonas aeruginosa strains, and 10 carbapenem-resistant Stenotrophomonas maltophilia strains showed a susceptibility rate of 100% to CFDC. Only one bla_NDM-positive Acinetobacter baumannii isolate was resistant to CFDC.
These results suggest that CFDC is an effective antimicrobial agent for the treatment of infections caused by multidrug-resistant gram-negative rods.

Key word

cefiderocol, carbapenem-resistant Enterobacterales, Pseudomonas aeruginosa, Stenotrophomonas maltophilia, Acinetobacter baumannii

Received

April 22, 2025

Accepted

July 28, 2025

Jpn. J. Chemother. 73 (6): 614-620, 2025