Vol.74 No.1 January 2026
A case of catheter-related bloodstream infection caused by Candida guilliermondii that was successfully treated with fosfluconazole
1)Department of Pharmacy, Seikeikai Hospital, 1-1-1 Minamiyasui, Sakai-ku, Osaka, Japan
2)Lehmann program, Kyoto Pharmaceutical University
3)Department of Internal Medicine, Seikeikai Hospital
Abstract
In Japan, Candida guilliermondii is rarely identified as a causative organism of candidemia associated with catheter-related bloodstream infection (CR-BSI). We report a case in which treatment with fosfluconazole (F-FLCZ) was clinically effective in a patient with CR-BSI caused by C. guilliermondii. The patient was a woman in her 80s who was hospitalized for disuse syndrome and was receiving nutritional management via a peripherally inserted central catheter (PICC). When she developed fever, an interim report of a blood culture collected during a febrile episode indicated the presence of yeast-like fungi. We removed the PICC and initiated the patient on F-FLCZ treatment. The causative organism was subsequently identified as C. guilliermondii, with an MIC of fluconazole of 16 μg/mL; however, since repeat blood culture confirmed negative conversion, F-FLCZ treatment was completed after a total of 26 days of administration. For our patient with CR-BSI caused by C. guilliermondii, we selected antimicrobial therapy based on the results of a blood culture and achieved clinical cure through treatment with F-FLCZ.
Key word
Candida guilliermondii, catheter-related bloodstream infection, fosfluconazole
Received
July 29, 2025
Accepted
October 15, 2025
Jpn. J. Chemother. 74 (1): 40-44, 2026
