Vol.52 No.5 May 2004
Cefdinir concentrations in human serum and oral tissues following a single oral administration
1)Department of Oral Surgery and 2)Department of Pharmacology, Nihon University School of Dentistry at Matsudo Nihon University,
2-870-1 Sakaecho-nishi, Matsudo, Chiba, Japan
Abstract
Cefdinir (CFDN) concentrations in human serum, gingiva, mandibular bone, and dental follicle following a single oral administration of CFDN (200 mg) were studied. The mean concentrations in serum, gingiva, mandibular bone, and dental follicle peaked at identical times, 3.5 h after administration, and were 1.39 μ g/mL, 0.60, 0.25, and 0.51 μ g/g. The mean concentration ratios of gingiva/serum, mandibular bone/serum, and dental follicle/serum at the peak were 0.42, 0.18, and 0.35. Most of the CFDN concentrations in gingiva, mandibular bone, and dental follicle exceed the MIC for 80% of clinically isolated strains of oral streptococci. CFDN may thus be a valuable antimicrobial agent for the treatment of odontogenic infection.
Key word
cefdinir, CFDN, penetration into oral tissue
Received
March 11, 2004
Accepted
April 15, 2004
Jpn. J. Chemother. 52 (5): 265-269, 2004
