Vol.52 No.6 June 2004
Adverse effects of antimicrobial agents The mechanisms of their concentration-dependent effects
Department of Pharmacology (I), Jikei University School of Medicine, 3-25-8 Nishi-Shinbashi, Minato-ku, Tokyo, Japan
Abstract
Recently many antimicrobial agents are used for treatment of infectious diseases. These agents are known to potentially have adverse effects. The adverse effects of antimicrobial agents are classified to two major groups; 1) concentration-independent effects and 2) concentration-dependent effects. Large part of the mechanism of these adverse effects remains unclear. In this paper, we will discuss the mechanisms of aminoglucoside- and glycopeptide-induced nephropathy, aminoglycoside-induced ototoxicity, β -lactam- and quinolone-induced convulsions, cephem-induced bleeding tendency and antabuse-like effect, and quinolone-induced hypeglycemia.
Key word
antimicrobial agents, adverse effect, mechanism
Received
May 6, 2004
Accepted
May 26, 2004
Jpn. J. Chemother. 52 (6): 293-303, 2004
