Vol.52 No.8 August 2004
In vitro antimicrobial activity of cefcapene against clinical isolates of various bacterial species from adult oral infections
Department of Oral Surgery, School of Medicine, Tokai University, Boseidai, Isehara, Kanagawa, Japan
Abstract
We organized bacteriological by analyzed pathogens causing infection in dentistry and oral surgery in adults for which oral antibiotics were used.
1) 331 strains were isolated from 145 cases, including 84 of periodontitis, 51 of jaw osteitis, and 10 of pericoronitis treated at 3 primary and 9 secondary medical practice facilities nationwide.
2) No difference was seen between primary and secondary facilities in the ratio of erobic and anerobic bacteria, infection type, and microorganisms distribution.
3) By bacterial strain, oral Streptococcus bacteria, including 40 Streptococcus constellatus strains, constituted 80.6% of erobic bacteria. Peptostreptococcus spp. was dominant at 44.3% of anerobic bacteria, followed by 25.9% of Prevotella spp.
4) When 4 antibacterial drugs were analyzed by cumulative MIC of 0.39 μ g/mL, the order was as follows: AMPC (90%), CFPN (89%), CFDN (81%), and CAM (76%).
5) The sensitivity of oral Streptococci was examined from antibacterial activity in the clinical trial for CFPN-PI and in the present study, which took place 10 years later. At MIC below 0.05 μ g/mL, sensitivity was lower in the present study, but at a MIC of 0.39 μ g/mL, at which clinical efficacy was expected to be optimal, it was similar at 96.9% compared to 97.4%.
6) Very few differences were seen in antibacterial activity between primary and secondary institutions.
Key word
oral infection, cefcapene pivoxil, postmarketing surveilance
Received
May 21, 2004
Accepted
June 17, 2004
Jpn. J. Chemother. 52 (8): 393-400, 2004
