Vol.52 No.8 August 2004
In vitro activity of faropenem and some other antibacterial agents against anaerobic bacteria isolated from 1998 to 2002
1)Division of Anaerobe Research, Gifu University Life Science Research Center, 1-1 Yanagido, Gifu, Japan
2)Drug Safety &, PMS Dept., Daiichi Suntory Pharma Co., Ltd.
3)QA &, RA Div., Pharmacovigilance Dept., Yamanouchi Pharmaceutical Co., Ltd.
Abstract
In vitro activity of faropenem (FRPM) against anaerobic species isolated in 1998, 2000, 2002 was investigated and compared with those of eight other oral agents and imipenem (IPM), as a post marketing surveillance of FRPM. The organisms tested comprised Bacteroides fragilis (25 strains in each year), Bacteroides thetaiotaomicron (25, 25, and 14 strains in 1998, 2000, 2002, respectively), pigmented Prevotella spp. (25, 24, and 25 strains in 1998, 2000, 2002, respectively), Propionibacterium acnes (25 strains in each year), and anaerobic gram-positive cocci (Peptostreptococcus anaerobius, Peptoniphilus asaccharolyticus, Finegoldia magna, and Micromonas micros) (25 strains in each year). FRPM was the most active oral agent against those anaerobes with the MIC90 of < 0.06 to 4 μ g/mL. Activity of FRPM was much the same as that of IPM to most of anaerobes tested. In comparison of the values of MIC50 and MIC90 during the period of this survey, any significant changes of those values for FRPM were not observed.
Key word
faropenem, anaerobe, susceptibility, post-market surveillance
Received
May 27, 2004
Accepted
July 13, 2004
Jpn. J. Chemother. 52 (8): 408-415, 2004
