Vol.52 No.10 October 2004
Influence of antimicrobial drugs on free bilirubin concentration in neonates
1)Department of Pharmacy, General Ota Hospital, Society of Health Insurance of Fuji Heavy Industries Ltd., 29-5 Hachimancho, Ota, Gunma, Japan
2)Department of Pediatrics, General Ota Hospital, Society of Health Insurance of Fuji Heavy Industries Ltd.
3)Department of Pediatrics, National Tokyo Medical Center
4)Department of Pediatrics, St. Marianna University School of Medicine, Yokohama City Seibu Hospital
5)Department of Infectious Diseases, Kitasato University School of Medicine
Abstract
We evaluated the influence of antimicrobial drugs on free bilirubin concentration in neonates. ABPC, CTX, and FMOX increased the free bilirubin concentration ratio to total bilirubin concentration [free bilirubin ratio (UB/TB)] , while CZOP and CAZ moderately increased UB/UT. CTRX and AZT affected UB/TB negligibly. Evaluation by birth weight showed a slight increase in UB/UT by ABPC, CTX, FMOX, CAZ, and CZOP in neonates with low birth weight, but CTRX and AZT had no influence on UB/UT. Total bilirubin concentration was significantly decreased compared to the control group after drug administration, while free bilirubin concentration was decreased only slightly. These results suggest that the 7 antimicrobial drugs slightly reduced plasma protein binding but negligibly influenced free bilirubin concentration and may thus be safe for use in the neonates.
Key word
neonate, antimicrobial agent, serum bilirubin
Received
July 27, 2004
Accepted
September 10, 2004
Jpn. J. Chemother. 52 (10): 574-582, 2004
