Vol.52 No.12 December 2004

Sepsis caused by methicillin-resistant Staphylococcus aureus (MRSA) without effects of vancomycin (VCM), teicoplanin (TEIC) and arbekacin (ABK) treated successfully and safely with intravenous administration of linezolid (LZD)

Shinya Ohkouchi¹⁾, Kazunori Gomi¹⁾, Yutaka Tokue^1,2), Toshiaki Kikuchi¹⁾, Shigeru Fujimura³⁾, Toshihiro Nukiwa¹⁾ and Akira Watanabe¹⁾

¹⁾Respiratory Oncology and Molecular Medicine, Institution of Development, Aging and Cancer, Tohoku University, 4-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi, Japan
²⁾Bacteriology and Infection Control, Graduate School of Medicine, Gunma University
³⁾Department of Microbiology, School of Nursing, Miyagi University

Abstract

A 77 year old man with sepsis caused by MRSA, that could not be treated by VCM, TEIC or ABK suffered severe renal failure and required immediate hemodialysis. He also suffered DIC and liver dysfunction. The administration of LZD 600 mg/day by intravenous injection ameliorated sepsis and DIC, and renal and liver function improved. LZD is thus effective in patients with sepsis caused by MRSA for whom other are ineffective drugs or who suffer severe organ dysfunction.

Key word

linezolid, MRSA, septicemia

Received

September 22, 2004

Accepted

November 24, 2004

Jpn. J. Chemother. 52 (12): 787-792, 2004