Vol.53 No.4 April 2005

Antichlamydial activity of telithromycin against Chlamydia trachomatis -Antichlamydial activity against fresh clinical isolates of C. trachomatis-

Ariaki Nagayama

Department of Microbiology and Immunology, Fukuoka University School of Medicine,
7-45-1 Nanakuma, Jonan-ku, Fukuoka, Japan

Abstract

The in vitro antichlamydial activity of telithromycin (TEL) against fresh clinical isolates of Chlamydia trachomatis (18 isolates) from patients with cervicitis in 1999 (April to August) was examined versus clarithromycin (CAM), erythromycin (EM), and azithromycin (AZM).
Results showed that the MIC range and MIC₉₀ were TEL (0.008-0.031 μg/mL, 0.031 μg/mL), CAM (0.008-0.031 μg/mL, 0.031 μg/mL), EM (0.125-0.25 μg/mL, 0.25 μg/mL), and AZM (0.063-0.25 μg/mL, 0.25 μg/mL).
TEL showed high antichlamydial activity similar to CAM and was about 8 times as potent as EM and AZM in MIC₉₀.
This suggests that TEL is clinically effective against C. trachomatis infections.

Key word

telithromycin, Chlamydia trachomatis, antimicrobial actirity

Received

December 16, 2004

Accepted

January 26, 2005

Jpn. J. Chemother. 53 (4): 274-276, 2005