Vol.53 No.8 August 2005
Cefdinir concentrations in human serum and jaw cyst following a single oral administration
Department of Oral Surgery and Department of Oral Molecular Pharmacology, Nihon University School of Dentistry at Matsudo Nihon University, 2-870-1 Sakaecho-nishi, Matsudo, Chiba, Japan
Abstract
Cefdinir (CFDN) concentrations in human serum and jaw cyst following a single oral administration of CFDN (200 mg) were studied. The mean concentrations in serum, cyst wall, and cyst fluid peaked at identical times, 3.5 h after administration, and were 1.94 μg/mL, 0.69 μg/g and 0.22 μg/mL, respectively. The mean concentration ratios of cyst wall/serum, cyst fluid/serum, and cyst fluid/cyst wall at the peak time were 0.37, 0.12, and 0.33, respectively. Most of the CFDN concentrations in jow cyst exceed the MIC for 80% of clinically isolated strains of oral streptococci. Thus, CFDN may be a valuable antimicrobial agent for the oral surgery.
Key word
cefdinir, jaw cyst, tissue penetration
Received
April 20, 2005
Accepted
July 15, 2005
Jpn. J. Chemother. 53 (8): 488-491, 2005
