Vol.53 No.S-1 July 2005

Antibacterial activitiy of doripenem against β-lactamase-producing strains

Ryoichi Okamoto, Ryuichi Nakano, Yuko Sato and Matsuhisa Inoue

Department of Microbiology, Kitasato University School of Medicine,
1-15-1 Kitasato, Sagamihara, Kanagawa, Japan

Abstract

We studied the in vitro antibacterial activity of doripenem (DRPM), a novel carbapenem, compared to imipenem, cefotaxime, ceftazidime, and cefepime, against β-lactamase-producing bacteria. DRPM was active against class A strains, including extended-apectrum β-lactamase (ESBL), and against class C and D producers, but not against class B. DRPM activity against β-lactamase producers was 2-4 times stronger than that of IPM.

Key word

doripenem, β-lactamase, antibacterial activity

Received

January 31, 2005

Accepted

March 1, 2005

Jpn. J. Chemother. 53 (S-1): 47-51, 2005