Vol.53 No.9 September 2005

In vitro activity of prulifloxacin against clinical isolates causing otorhinolaryngological infections

Yoshifumi Uno

Uno ENT Clinic, 3702-4 Tomihara, Okayama, Japan

Abstract

Between June 2003 and January 2004, we studied the in vitro activity of prulifloxacin (PUFX) against clinical isolates causing otorhinolaryngological infection: coagulase negative Staphylococcus (CNS), Staphylococcus aureus, α-Streptococcus, Streptococcus pneumoniae, Corynebacterium spp., Branhamella catarrhalis, and Haemophilus influenzae.
1) MIC₈₀ and MIC₉₀ for CNS were 4.0 μg/mL, and susceptibility distribution showed two peaks, at 0.125 μg/mL and 4.0 μg/mL.
2) MIC₈₀ and MIC₉₀ for S. aureus were 0.5 μg/mL and 8.0 μg/mL, and susceptibility distribution showed two peaks, at 0.25 μg/mL and 0.5 μg/mL.
3) MIC₈₀ and MIC₉₀ for α-Streptococcus were 4.0 μg/mL, and susceptibility distribution showed one peak, at 2.0 μg/mL.
4) MIC₈₀ and MIC₉₀ for S. pneumoniae were 2.0 μg/mL, and susceptibility distribution showed two peaks, at 1.0 μg/mL and 2.0 μg/mL.
5) MIC₈₀ and MIC₉₀ for Corynebacterium spp. were 8.0 μg/mL and 32.0 μg/mL, and susceptibility distribution showed two peaks, at 0.5 μg/mL and 32.0 μg/mL.
6) MIC₈₀ and MIC₉₀ for B. catarrhalis were 0.125 μg/mL, and susceptibility distribution showed one peak, at 0.125 μg/mL.
7) MIC₈₀ and MIC₉₀ for H. influenzae were 0.031 μg/mL, and susceptibility distribution showed one peak, at 0.031 μg/mL.
Compared to other new quinolone antimicrobial agents for Gram-positive bacteria-except gatifloxacin (GFLX), which showed good activity-PUFX showed activity almost equal to that of ciprofloxacin (CPFX) and levofloxacin (LVFX). For Gram-negative bacteria, PUFX showed activity almost equal to that of GFLX, CPFX, and LVFX. We concluded that we get good results with PUFX in patients with otorhinolaryngological infection caused by the above strains.

Key word

prulifloxacin, otorhinolaryngological infection, clinical isolat organism, MIC

Received

July 6, 2005

Accepted

August 19, 2005

Jpn. J. Chemother. 53 (9): 512-525, 2005