Vol.53 No.10 October 2005
Simple determination of fluoroquinolones with high-performance liquid chromatography
1)Department of Practical Pharmacy, Kyoritu University of Pharmacy
2)Department of Pharmacology I, Jikei University School of Medicine, 3-25-8 Nishi-Shinbashi, Minato-ku, Tokyo, Japan
Abstract
To use fluoroquinolones effectively and safely, pharmacokinetic/pharmacodynamic (PK/PD) analysis is strongly recommended. The plasma concentration of fluoroquinolones in the patients is necessary for PK/PD analysis. We established new HPLC system with a fluorescent detector enabling us to determine the concentration of 9 fluoroquinolones-ciprofloxacin, enoxacin, gatifloxacin, levofloxacin, lomefloxacin, moxifloxacin, norfloxacin, pazufloxacin, tosufloxacin-only by changing excitation and emission wave length. We suggest that this is useful for the determination of plasma concentrations of fluoroquinolones in patients and essential for PK/PD analysis.
Key word
fluoroquinolone, high performance liquid chromatography
Received
August 29, 2005
Accepted
September 20, 2005
Jpn. J. Chemother. 53 (10): 619-622, 2005
