Vol.53 No.S-3 December 2005
In vitro antibacterial activity of moxifloxacin against anaerobic and facultative bacteria
Division of Anaerobe Research, Life Science Research Center, Gifu University, 1-1 Yanagido, Gifu, Japan
Abstract
Moxifloxacin (MFLX), a new synthetic antibacterial, was assessed for in vitro antibacterial activity against anaerobic and facultative bacteria in comparison with cefdinir (CFDN), clavulanic acid/amoxicillin (CVA/AMPC), clarithromycin (CAM), clindamycin (CLDM) and levofloxacin (LVFX). The results obtained are describe below.
1. MFLX showed antibacterial activity against a broad spectrum of reference strains of anaerobic and facultative bacteria, ranging from gram-positive to gram-negative. The MICs of MFLX were ≤ 2 μg/mL for all of the strains except Clostridium clostridiiforme, C. ramosum, Lactobacillus acidophilus, and Lactobacillus plantarum.
2. The MICs of MFLX for clinical isolates, showed potent antibacterial activity (MIC: ≤ 0.5 μg/mL) against gram-positive cocci, except F. magna, and against Propionibacterium acnes, and gram-negative Prevotella inter media, Porphyromonas gingivalis, and Fusobacterium nucleatum. The antibacterial activity of MFLX was almost equal to that of CVA/AMPC. The activity of MFLX was also equal to or 4∼32 times greater than that of LVFX.
Key word
moxifloxacin, anaerobe, clinical isolate, MIC
Received
September 6, 2005
Accepted
November 21, 2005
Jpn. J. Chemother. 53 (S-3): 21-26, 2005
