Vol.54 No.3 May 2006

Antimicrobial susceptibilities of clinically isolated strains of Gardnerella vaginalis

Hinako Murakami¹⁾, Tetsuya Matsumoto²⁾, Morihiro Iwata¹⁾, Kumiko Yasui¹⁾, Chikako Maehara¹⁾, Nobuhiko Furuya^1,3), Yoshikazu Ishii³⁾, Kazuhiro Tateda^1,3) and Keizo Yamaguchi^1,3)

¹⁾Clinical Laboratory, Toho University Omori Medical Center,
6-11-1 Omori-nishi, Ota-ku, Tokyo, Japan
²⁾Department of Microbiology, School of Medicine, Tokyo Medical University
³⁾Department of Microbiology and Infectious Diseases, School of Medicine, Toho University

Abstract

We investigated the antimicrobial susceptibilities of Gardnerella vaginalis by using 607 strains of clinical isolates at Toho University Omori Medical Center from 2002 to 2004. Minimum Inhibitory Concentrations (MICs) of 17 antimicrobial agents were determined with micro broth dilution methods based on the guidelines of NCCLS. Penicillins, carbapenems, macrolides and glycopeptides antimicrobial agents showed potent activities of which the MIC₉₀ levels were 1 μg/mL or less. We could not find any major differences in the antimicrobial susceptibilities between our results and the results in some previous reports. We therefore insist that we can choose adequate antibiotic regimens for patients with G. vaginalis according to these results. Although we could not find any resistant strains against all antibiotics tested in this study, we think that further investigations should be needed to follow up the antimicrobial susceptibilities of clinical isolates of G. vaginalis.

Key word

Gardnerella vaginalis, antimicrobial susceptibility

Received

December 12, 2005

Accepted

March 3, 2006

Jpn. J. Chemother. 54 (3): 249-254, 2006