Vol.54 No.4 July 2006
Findings better predictors of drug-induced torsades de pointes
Department of Pharmacology, Interdisciplinary Graduate School of
Medicine and Engineering, University of Yamanashi,
1110 Shimokato, Chuo, Yamanashi, Japan
Abstract
Preclinical and clinical studies have indicated that only a very small number of patients with a diminished repolarization reserve in the heart suffer complications in drug-induced long QT syndrome by high-risk drugs. Drug assessment using sensitive, reliable in vivo proarrhythmia models provides important information to predicting the onset of TdP in such patients.
Key word
ECG, QT interval prolongation, arrhythmia, ICH, animal model
Received
March 7, 2006
Accepted
May 10, 2006
Jpn. J. Chemother. 54 (4): 303-307, 2006
