Vol.55 No.3 May 2007
An appropriate selection of antimicrobial agents for intractable otitis media
Department of Otolaryngology-Head and Neck Surgery, Wakayama Medical University,
811-1, Kimiidera, Wakayama, Japan
Abstract
The antimicrobial resistance of pathogens in otolaryngological infections such as acute otitis media, acute rhinosinusitis has been big problems in Japan and Asian countries. Such prevalence of drug-resistant microbes has been compelling force to reconsider the treatment guideline of infectious diseases. Rapid increase of intractable otitis media in children, however, might have been caused by several factors, i.e., immaturity of host immunity, drastic changes of life environment in children such as day-care attendance, short feeding with breast milk, and antimicrobial resistant pathogens. To cope with such intractable otitis media, we should select appropriate antimicrobial agents based on the treatment guideline using the scoring and severity system and employ approaches based on the PK/PD theory.
Key word
otitis media, guideline, PRSP, BLNAR, PK/PD
Received
October 30, 2006
Accepted
March 6, 2007
Jpn. J. Chemother. 55 (3): 201-210, 2007
