Vol.55 No.4 July 2007

Annual change of susceptibility of Pseudomonas aeruginosa isolated from lower respiratory tract or urinary tract infections against antibacterial agents (2^nd report)

Yoshikazu Ishii¹⁾, Akira Ohno¹⁾, Morihiro Iwata²⁾, Hinako Murakami²⁾ and Keizo Yamaguchi^{1, 2)}

¹⁾Department of Microbiology and Infectious Diseases, Toho University Faculty of Medicine, 5-21-16 Omori-nishi, Ota-ku, Tokyo, Japan
²⁾Department of Laboratory Medicine, Toho University Omori Medical Center

Abstract

The susceptibilities of Pseudomonas aeruginosa isolated from lower respiratory tract infections (402 strains) and urinary tract infections (215 strains) against various antibacterial agents were examined. The strains were clinically isolated between 2004 and 2005 at Toho University Omori Hospital. Susceptibility Rates (SR) were calculated according to break point of Clinical and Laboratory Standards Institute (CLSI). The SR tended to elevate overall compared to those we reported in 2003. The SR of major agent against strains isolated from lower respiratory tract infections and urinary tract infection (2004/2005, respectively) was: ceftazidime, 94.0%/91.6% and 90.0%/81.9%; imipenem, 67.5%/75.5% and 80.9%/69.5%; ciprofloxacin, 81.5%/85.6% and 76.4%/78.1%; amikacin, 99.0%/99.0% and 94.5%/98.1%. The decrease of SR of cephem antibiotics and the increase of multiply-resistant organism mainly isolated from urinary tract infection can be the subject of future discussions, which requires appropriate intervention.

Key word

MIC, Pseudomonas aeruginosa, lower respiratory tract infection, urinary tract infection, ceftazidime

Received

April 27, 2007

Accepted

May 29, 2007

Jpn. J. Chemother. 55 (4): 278-285, 2007