Vol.55 No.S-1 October 2007
Phototoxicity study of garenoxacin in guinea pigs
Research Laboratories, Toyama Chemical Co. Ltd., 2-4-1 Shimookui, Toyama, Japan
Abstract
The phototoxicity of Garenoxacin mesilate hydrate(GRNX) in guinea pigs was studied. In this study, the phototoxic potential of GRNX was compared to that of ciprofloxacin hydrochloride(CPFX) and levofloxacin(LVFX) as comparative articles.
Animals were administered a single dose intravenously with each article at the dose level of 100 mg/kg as free base, and irradiated with ultraviolet A(UVA) of about 10 J/cm2 for about 30 minutes starting at 10 minutes after administration. The skin reactions of these animals were observed macroscopically at 24 and 48 hours after irradiation. A control group was administered physiological saline.
GRNX showed no skin reaction after 24 and 48 hours. CPFX showed moderate skin reaction in all animals both after 24 and 48 hours. LVFX showed a slight skin reaction in one of six animals after 24 hours, but the skin reaction disappeared after 48 hours.
Plasma concentration of GRNX during irradiation (10 to 40 minutes after administration) with UVA was comparable to that of LVFX, and was higher than that of CPFX.
As mentioned above, we consider that the phototoxic potential of GRNX is weaker than that of CPFX and LVFX.
Key word
garenoxacin, des-fluoro(6)-quinolone, phototoxicity
Received
April 27, 2007
Accepted
August 22, 2007
Jpn. J. Chemother. 55 (S-1): 75-77, 2007
