Vol.56 No.S-1 April 2008
Effect of metal-ion on sitafloxacin absorption
Jikei University School of Medicine, 3-25-8 Nishi-shinbashi, Minato-ku, Tokyo, Japan
Abstract
The effect of antacid (aluminum hydroxide and magnesium oxide), calcium carbonate, and ferrous sulfate on pharmacokinetics of the fluoroquinolone sitafloxacin(STFX) was evaluated in two separate studies. Each study was a three-period crossover in 9 healthy adult male volunteers involving the administration of 100 mg STFX alone as a control treatment. STFX coadministration with aluminum hydroxide decreased the Cmax average to 18%, with magnesium oxide to 43%, with calcium carbonate to 63%, and with ferrous sulfate to 33%. STFX coadministration with aluminum hydroxide decreased the AUC0-24h average to 25%, with magnesium oxide to 49%, with calcium carbonate to 68%, and with ferrous sulfate to 44%. These results suggest that coadministering STFX with metal-ion reduced the STFX effect.
Key word
sitafloxacin, antacid, calcium carbonate, ferrous sulfate, pharmacokinetics
Received
October 5, 2007
Accepted
January 8, 2008
Jpn. J. Chemother. 56 (S-1): 25-31, 2008
