Vol.56 No.S-1 April 2008
Effect of ranitidine on sitafloxacin absorption
Jikei University School of Medicine, 3-25-8 Nishi-shinbashi, Minato-ku, Tokyo, Japan
Abstract
The effect of the H2 receptor antagonist (ranitidine hydrochloride) on pharmacokinetics of the fluoroquinolone sitafloxacin(STFX) was studied in 8 healthy adult male volunteers in a two-period crossover trial. AUC0-24h increased by 8% and Cmax by 4%, suggesting that ranitidine hydrochloride affected STFX pharmacokinetics negligibly, if at all.
Key word
sitafloxacin, H2 receptor antagonist, ranitidine, pharmacokinetics
Received
November 2, 2007
Accepted
January 8, 2008
Jpn. J. Chemother. 56 (S-1): 32-35, 2008
