Vol.57 No.1 January 2009
Susceptibility of Pseudomonas aeruginosa isolates from blood and other clinical specimens of same patients to antibacterial agents
1)Chemotherapy Division, Mitsubishi Chemical Medience Corporation, 3-30-1 Shimura, Itabashi-ku, Tokyo, Japan
2)School of Medicine, Toho University
Abstract
Of 49,998 blood specimens (24,999 cases) collected from hospitals in Japan between 2005 and 2006 and cultured, 207 from 148 cases were positive for Pseudomonas aeruginosa. The susceptibility of these isolates to antibacterial agents were examined. Resistance calculated based on Clinical and Laboratory Standard Institute break points was as follows: amikacin, 3.4%; piperacillin, tazobactam/piperacillin, meropenem, ceftazidime, and ciprofloxacin, 10.8-20.3%; and imipenem, 31.1%. Multidrug-resistant P. aeruginosa (MDRP) was detected in 6 of the 148 cases whose blood specimens were positive for P. aeruginosa. The production of metallo β-lactamase was detected in 4 of 6 MDRP isolates. P. aeruginosa was isolated in clinical specimens other than blood of 55 cases whose blood specimens were positive for the same species. Isolates from clinical specimens other than blood tended to be more resistant to antibacterial agents than isolates from blood specimens.
Clinical specimens other than blood of patients whose blood were positive for P. aeruginosa must thus be cultured so that appropriate treatment is provided and to better understand the microbiological characteristics and epidemiology of P. aeruginosa isolates from blood.
Key word
blood culture, multidrug-resistant Pseudomonas aeruginosa, metallo β-lactamase
Received
August 25, 2008
Accepted
December 2, 2008
Jpn. J. Chemother. 57 (1): 26-31, 2009
