Vol.57 No.2 March 2009
Clinical studies of clavulanate acid/amoxicillin (1 : 14 ratio) in children with pneumonia
Department of Pediatrics, Asahikawa Kosei Hospital, 1-24 Asahikawa, Hokkaido, Japan
Abstract
Between January 2008 and October 2008, 58 children with pneumonia with CRP exceeding 2 mg/dL were treated with clavulanate acid/amoxicillin(CVA/AMPC) as outpatients and evaluated for clinical efficacy. Patients were 6 months to 3 years old. CVA/AMPC was administered orally at a daily dose of 90 mg/kg as AMPC 2 times a day before meals for 3 to 5 days. The clinical efficacy of 7 patients could not be evaluated because they were hospitalized within 3 days after CVA/AMPC treatment. Clinical efficacy rate 98.0% (50/51). The patient evaluated as poor was infected with Haemophilus influenzae (MIC to ampicillin: 12 μg/mL). Adverse effects were diarrhea or loose stool observed in 26 patients (44.8%) and rash in 1 (1.7%).
Key word
pneumonia, clavulanate acid/amoxicillin, Haemophilus influenzae, Streptococcus pneumoniae, child
Received
October 31, 2008
Accepted
January 29, 2009
Jpn. J. Chemother. 57 (2): 101-105, 2009
