Vol.57 No.S-1 March 2009
Effect of gastric pH-raising drugs on tebipenem pivoxil fine granules pharmacokinetics in healthy male volunteers
1)Hamamatsu Institute of Clinical Pharmacology & Therapeutics, 40-3 Sukenobu, Naka-ku, Hamamatsu, Shizuoka, Japan
2)Clinical Research Department, Meiji Seika Kaisha, LTD.
Abstract
We assessed the effect of gastric pH-raising drugs such as famotidine and dried aluminium hydroxide gel magnesium hydroxide on the pharmacokinetics of tebipenem pivoxil(TBPM-PI) fine granules, an oral carbapenem antibiotic and TBPM prodrug.
We assessed the pharmacokinetics of TBPM-PI fine granules at 200 mg (potency) when administered combined with 20 mg of famotidine or with 896 mg of dried aluminium hydroxide gel, 800 mg of magnesium hydroxide. Cmax was lowered to 40-60%, AUC0-∞ to 70-80% and urinary excretion to 80% of that after administration of TBPM-PI alone.
We concluded that appropriate dose and regimen are recommended when TBPM-PI fine granules are administered with gastric pH-raising drugs, given that such drugs influence TBPM-PI pharmacokinetics.
Key word
tebipenem pivoxil, drug interaction, famotidine, antacid, pharmacokinetics
Received
October 15, 2008
Accepted
December 18, 2008
Jpn. J. Chemother. 57 (S-1): 99-102, 2009
