Vol.57 No.4 July 2009

Clinical response to 7-day treatment with cefcapene pivoxil 300 mg qd for acute uncomplicated cystitis -Comparison of clinical response between Days 3 and 7 of administration-

Soichi Arakawa¹⁾, Katsumi Shigemura¹⁾, Yuzo Nakano¹⁾, Kazushi Tanaka¹⁾, Masato Fujisawa¹⁾, Akira Fujii²⁾, Toshihiko Mita³⁾, Nobuo Kataoka⁴⁾, Osamu Matsumoto⁵⁾, Minoru Hazama⁶⁾, Takashi Matsui⁷⁾, Sadao Kamidono⁷⁾, Shinichi Morishita⁸⁾, Masayuki Kuwayama⁹⁾ and Nobumasa Kataoka¹⁰⁾

¹⁾Department of Urology, Kobe University Hospital, 7-5-2 Kusunokicho, Chuo-ku, Kobe, Hyogo, Japan
²⁾Department of Urology, Shinnittetsu Hirohata Hospital
³⁾Mita and Terasoma Urological Clinic
⁴⁾Department of Urology, Nishiwaki Municipal Hospital
⁵⁾Department of Urology, Miki Municipal Hospital
⁶⁾Department of Urology, Yodogawa Christian Hospital
⁷⁾Department of Urology, Kobe Red Cross Hospital
⁸⁾Department of Urology, Kanebo Memorial Hospital
⁹⁾Department of Urology, Shisoh General Hospital
¹⁰⁾Faculty of Health Science, Kobe University School of Medicine

Abstract

We compared clinical day 3 and 7 response to oral cefcapene pivoxil (300 mg qd) in 70 women aged 18 to 69 with acute uncomplicated cystitis. Patient conditions met those specified in Efficacy Evaluation Criteria for Drugs in the Treatment of Urinary Tract Infections (Ver. 4, Provisional Draft). On day 3, overall clinical response was excellent in 47 of the 70 (67%), good in 22 (31%), and poor in 1 (1%) (combined excellent-good response: 99%). On day 7, overall clinical response was excellent in 53 (76%) and good in 17 (24%) (combined excellent-good response: 100%). The causative pathogen was E. coli in 58 (83%), with E. coli alone isolated in 53. Bacteriological effect (elimination) against 78 isolates was 92% (72/78 strains) on day 3 and 94% (73/78 strains) on day 7. Urination pain and other subjective symptoms disappeared in 61 (87%), were alleviated in 8 (11%) and remained unchanged in 1 (1%) on day 3 (improvement (normalized+alleviated): 99%). All symptoms had disappeared in all patients (100%) on day 7. No statistically significant difference was seen in day 3 and 7 assessments of pyuria, bacteriuria, or overall clinical response. Subjective symptom, response on day 3 was not inferior to that on day 7 in terms of objective data. Our results indicate that 3 days of treatment for acute uncomplicated cystitis with CFPN-PI may suffice, pointing the need to the validity of further assessment.

Key word

cefcapene pivoxil, acute uncomplicated cystitis, The UTI Criteria

Received

October 7, 2008

Accepted

May 19, 2009

Jpn. J. Chemother. 57 (4): 304-310, 2009