Vol.58 No.3 May 2010
Antimicrobial susceptibility of organisms isolated in 2006 and 2007 cases of complicated urinary tract infection
Department of Urology, Graduate School of Medical and Dental Sciences, Kagoshima University, 8-35-1 Sakuragaoka, Kagoshima, Japan
Abstract
Based on MICs determined using agar dilution, we determined the antibacterial activity of 18 antibiotics, including 5 carbapenems, against 132 strains isolated from complicated urinary tract infection(c-UTI) cases treated between January 2006 and December 2007. Of the 20 Enterococcus faecalis strains, 70 Escherichia coli, 8 Klebsiella pneumoniae, and 34 Pseudomonas aeruginosa examined, teicoplanin, vancomycin, and ampicillin were strongly active against E. faecalis. Carbapenems showed good activity against E. faecalis. Among clinical Gram-negative bacteria isolates, carbapenems were active against almost all strains of Enterobacteriaceae, but fluoroquinolone-resistant E. coli has been increasing since 2000. E. coli resistant to fluoroquinolone accounted for 25%. Against clinical P. aeruginosa isolates, MIC90 of carbapenems was ≥16 mg/L, and resistance is increasing. Four strains of multidrug-resistant P. aeruginosa were isolated. Urinary isolate resistance to antimicrobials is also increasing, but the carbapenem meropenem has remained outstanding as the antibacterial drug of empiric choice in cases of severe c-UTI.
Key word
urinary tract infection, drug susceptibility, drug resistance, fluoroquinolone, carbapenem
Received
October 23, 2009
Accepted
March 16, 2010
Jpn. J. Chemother. 58 (3): 248-252, 2010
