Vol.58 No.4 July 2010
Do doctors know of and use PK-PD-based antimicrobial agent dosage?
1)Department of Practical Pharmacy, Keio University Faculty of Pharmacy, 1-5-30 Shibakoen, Minato-ku, Tokyo, Japan
2)Department of Pediatrics, National Hospital Organization Tokyo Medical Center
3)Department of Surgery, Toho University Ohashi Medical Center Hospital
4)Pharmaceuticals and Medical Devices Agency
5)Department of Pediatrics, Fuji Heavy Industries Ltd. Health Insurance Society General Ota Hospital
6)Department of Pharmacy, Fuji Heavy Industries Ltd. Health Insurance Society General Ota Hospital
7)Department of Respiratory Medicine, Yamagata Saisei Hospital
8)Department of Microbiology, and Infectious Diseases, Toho University School of Medicine
9)Department of Pharmacology, Jikei University School of Medicine
Abstract
Pharmacokinetic-pharmacodynamic(PK-PD) analysis is important in selecting the antimicrobial agent dosage for appropriate use. No information on the spread of dosage determination based on PK-PD analysis has, to our knowledge, been reported. We studied how the PK-PD concept spread in the clinical field. Among respondents, 55% of doctors knew of the PK-PD concept, which 66% evaluated as very useful. They determined the dosage of carbapenems (78% of doctors), aminoglycosides (77%), and injectable cephems (75%) based on the PK-PD concept. Of these doctors, however, 55% determined the dosage of quinolones based on this concept. We suggest that training in PK-PD analysis and dosage determination based on PK-PD is important and urgent in appropriate antimicrobial agent use.
Key word
antimicrobial agents, PK-PD, dosage, questionnaire survey
Received
June 8, 2009
Accepted
April 13, 2010
Jpn. J. Chemother. 58 (4): 460-465, 2010
