Vol.58 No.6 November 2010
Characteristics of New Delhi metallo-β-lactamase (NDM-1), a novel carbapenem resistance factor
Department of Microbiology and Infectious Diseases, Faculty of Medicine, Toho University School of Medicine, 5-21-16 Omori-nishi, Ota-ku, Tokyo, Japan
Abstract
A novel metallo-β-lactamase NDM-1 -New Delhi metallo-β-lactamase-1- was named and reported by Yong et al. in 2009. NDM-1-producing multidrug-resistant Escherichia coli and Klebsiella pneumoniae isolates were reported in the United States and United Kingdom. Like other plasmidic metallo-β-lactamases, NDM-1 hydrolyzes most β-lactams with the exception of monobactams. Typically, blaNDM-1 is detected in E. coli or K. pneumoniae isolated from undergoing healthcare exposure in India, Bangladesh, or Pakistan. In Japan, an NDM-1-producing E. coli was isolated in 2009 from a subject at University Hospital in Tochigi Prefecture who had been hospitalized in India. Although few basic studies on NDM-1 and the epidemiology of NDM-1-producing isolates exist, I review and discuss blaNDM-1, NDM-1-producing bacteria, and bacteria detection.
Key word
β-lactamase, carbapenemase, NDM-1
Received
September 13, 2010
Accepted
September 21, 2010
Jpn. J. Chemother. 58 (6): 639-643, 2010
