Vol.59 No.2 March 2011
Approach for the management of infectious diseases due to antimicrobial agent-resistant pathogens
1)Infection Control Center, Oita University Hospital, 1-1 Idaigaoka, Hasama-machi, Yufu, Oita, Japan
2)Internal Medicine II, Oita University Faculty of Medicine
Abstract
The rapid spread of multidrug-resistant organisms such as Pseudomonas aeruginosa and the Acinetobacter sp. has caused a very serious problem in the treatment of infectious diseases caused by those bacteria. To manage their spread, the use of appropriate antimicrobial agents as a preventative measure is recommended and it is essential to intensify infection control both in hospitals and the community. However measures being taken now are not enough for the prevention and management of disease related with these multidrug-resistant organisms because they are expected to spread even further in the future. Development of new antimicrobial agents and treatment with new mechanical agents, other than antimicrobial measures such as the use of macrolides, are needed in the near future. Furthermore, antibacterial peptides, antibacterial antibodies and vaccines against multidrug-resistant organisms should be developed both for treatment and prevention. A new approach, based on not only the development of new antimicrobial agents but also other antibacterial strategies, is necessary for the management of drug-resistant organisms.
Key word
drug-resistance, infection control, PK-PD, biofilm, vaccine
Received
February 8, 2011
Accepted
February 15, 2011
Jpn. J. Chemother. 59 (2): 151-157, 2011
