Vol.60 No.1 January 2012
Breakpoints and pharmacokinetic-pharmacodynamic theory for respiratory infections and sepsis
1)Infection Control Center, Oita University Hospital, 1-1 Hasamamachiidaigaoka, Yufu, Oita, Japan
2)Internal Medicine II, Oita University Faculty of Medicine
Abstract
It is difficult to select an adequate antimicrobial agent for the treatment of infectious diseases because the spread of drug-resistant pathogens. Antimicrobial susceptibility testing and the evaluation of the derived minimum inhibitory concentration(MIC) have been important to decide on the appropriate therapy. Since 1994, the Japanese Society of Chemotherapy has determined the clinical breakpoints of various antimicrobial agents. On the other hand, it has been revealed in the last decade that pharmacokinetic-pharmacodynamic (PK-PD) parameters were well correlated to bacteriological and clinical outcomes of agents. Although the breakpoints of the Japanese Society of Chemotherapy are associated with a part of the PK-PD principles, a discrepancy also exists between the calculation formula for those breakpoints and the PK-PD principles. Because useful and scientific breakpoints are needed in Japan, ongoing discussions for the breakpoints in the near future should be held among all of the members of the Japanese Society of Chemotherapy.
Key word
respiratory infection, sepsis, breakpoint, PK-PD
Received
November 20, 2011
Accepted
December 12, 2011
Jpn. J. Chemother. 60 (1): 12-17, 2012
