Vol.60 No.6 November 2012
Fundamental approach to translational research in the clinical microbiology field -Experience of 21 years as a researcher-
Toho University School of Medicine, 5-21-16 Omori-nishi, Ota-ku, Tokyo, Japan
Abstract
It was a great honor for me that we have reported several novel pieces of evidence and facts from the standpoint of translational research. First, we have reported new insights in pathogenesis and therapeutic strategies in gut-derived Pseudomonas aeruginosa sepsis in neutropenic mice. During those experiments, quorum-sensing suppressing activity of macrolide at sub-MICs was demonstrated in P. aeruginosa, which was speculated to be one of mechanisms of this antibiotic against chronic pulmonary infections. Clinical and epidemiological surveys and a mouse model of experiments have shed light on the pathogenesis of Legionella pneumonia and gave new insight into this disease. One of the most impressive and important reports on antibiotic resistance and its mechanism is the discovery and characterization of the first extended spectrum β-lactamase (ESBL), which was later named "Toho-type ESBL". Thinking back, I was so lucky to be in Toho University, and I would like to express my deepest appreciation to all the people who were concerned with those data and studies, and in particular I would like to give special thanks to our laboratory members for their sincere efforts and contribution.
Key word
translational research, quorum-sensing, extended spectrum β-lactamase, Legionella, endogenous sepsis
Received
August 21, 2012
Accepted
August 30, 2012
Jpn. J. Chemother. 60 (6): 627-634, 2012
