Vol.61 No.1 January 2013
Analysis of the situation of isolation and drug susceptibilities of yeast-like fungi in Gunma University Hospital
1)Department of Clinical Laboratory Center, Gunma University Hospital, 3-39-15 Showa-machi, Maebashi, Gunma, Japan
2)Department of Infection Control, Gunma University Hospital
Abstract
We examined the frequency of isolation and the drug susceptibility of yeast-like fungi in Gunma University Hospital. Almost a half of the yeast-like fungi isolated were from the respiratory specimens from each year, and the major species isolated were Candida albicans, Candida glabrata, Candida tropicalis, Candida parapsilosis and Candida krusei. Some strains of C. tropicalis, C. krusei and C. glabrata were resistant against fluconazole. The distribution of the range of MICs of the isolated non-albicans Candida species against miconazole was wide. Both C. krusei and C. glabrata showed elevated MICs against voriconazole. Ninety-one point seven percent of C. glabrata isolates were resistant against itraconazole. One of the C. tropicalis isolates was resistant to micafungin having an MIC>16 μg/mL. Eighty percent of C. krusei isolates showed resistance to flucytosine.
These results indicate that MICs against drugs had a variety of distributions among the Candida species. In conclusion, our data suggest that, for proper treatment of target fungi, appropriate drugs should be selected based on the results of the identification of the target fungi and the susceptibility test.
Key word
yeast-like fungi, drug susceptibility
Received
August 31, 2012
Accepted
November 20, 2012
Jpn. J. Chemother. 61 (1): 5-9, 2013
