Vol.62 No.2 March 2014
Studies on the mechanisms of antimicrobial resistance -Elucidation of the natural resistance mechanism in bacteria-
Kyoto Pharmaceutical University, 5 Nakauchi-cho, Misasagi, Yamashina-ku, Kyoto, Japan
Abstract
In my life of study for about 32 years in the Department of Microbiology at Kyoto Pharmaceutical University, I was able to obtain a great deal of data on the resistant mechanism of antimicrobial-resistant bacteria. In this review, I would like to explain about some of the experimental results of the following studies, (1) Most gram-negative bacteria are resistant to macrolide antibiotics, but some gram-negative bacteria such as Moraxella catarrhalis and Haemophilus influenzae exhibit hyper-susceptibility to macrolides. Why are macrolides so active against some gram-negative bacteria? (2) Regarding the tolerant phenomenon observed with Staphylococcus aureus treated with β-lactam antibiotics. (3) Pseudomonas aeruginosa shows high susceptibility to carbapenem antibiotics such as imipenem, meropenem and doripenem, but P. aeruginosa exhibits high intrinsic resistance to penem antibiotics such as faropenem, ritipenem and sulopenem. Why are penem antibiotics not active against P. aeruginosa?
Finally, I would like to express my deepest appreciation on winning the "Shiga Kiyoshi・Hata Sahachiro Prize", and to express my sincere thanks and appreciation to our laboratory staff members and all the people who made such continuous efforts both day and night.
Key word
macrolides, M. catarrhalis, β-lactams, S. aureus, intrinsic resistance, P. aeruginosa
Received
January 24, 2014
Accepted
January 31, 2014
Jpn. J. Chemother. 62 (2): 177-191, 2014
