Vol.63 No.2 March 2015
CTX-M-type ESBL-producing Escherichia coli isolates from animals
1)Joint Department of Veterinary Medicine, Faculty of Agriculture, Tottori University, Minami 4-101, Koyama, Tottori, Japan
2)United Graduate School of Veterinary Science, Gifu University
Abstract
In veterinary medicine, antimicrobial drugs have been used mainly for treatment of bacterial infections in domesticated and food-producing animals. In recent years, third-generation cephalosporins have been approved and distributed as veterinary drugs, raising the risk of selection of extended-spectrum βlactam-producing bacteria in animals. Notably, CTX-M-type β-lactamases, which are prevailing in human medicine, have been the major type of ESBLs in bacteria of animal origin. It has been demonstrated that antimicrobial-resistant bacteria in animals can become a significant concern not only in veterinary medicine but also for the general public health, because these bacteria run the risk of direct or indirect transfer from domesticated and food-producing animals to humans. Escherichia coli is a representative commensal bacterium prevalent in various kinds of animals and is therefore regarded as a reservoir of antimicrobial resistance. Furthermore, this bacterium is a major pathogen causing various bacterial infections in both domesticated and food-producing animals. This review outlines the prevalence of CTX-M-type ESBL-producing E. coli isolates from domesticated and food-producing animals mainly in Japan.
Key word
E. coli, extended-spectrum β-lactamases (ESBL), Japanese Veterinary Antimicrobial resistance monitoring system
Received
December 12, 2014
Accepted
December 25, 2014
Jpn. J. Chemother. 63 (2): 181-186, 2015
