Vol.64 No.5 September 2016
Impaired neutrophil function in patients with diabetes
Department of Microbiology and Immunology, Teikyo University School of Medicine, 2-11-1 Kaga, Itabashi-ku, Tokyo, Japan
Abstract
Diabetes mellitus increases the susceptibility to infection by altering both innate and adaptive immune systems. The main reason why diabetes predisposes an individual to infection appears to be abnormalities in host response, particularly in neutrophil chemotaxis, adhesion and phagocytosis, intracellular killing, and neutrophil extracellular traps (NETs), which are defects that have been attributed to the effect of hyperglycemia. Evidence of defects in serum opsonic activity as a result of hyperglycemia also exists. Here, the literature on neutrophil dysfunctions in diabetes and hyperglycemia is reviewed. In addition, the effects of diabetes treatment on the neutrophil response are discussed.
Key word
neutrophils, innate immune system, diabetes mellitus, hyperglycemia
Received
June 21, 2016
Accepted
August 5, 2016
Jpn. J. Chemother. 64 (5): 735-741, 2016
