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Abstract

Vol.65 No.3 May 2017

A proposal for the future for the Japanese Society of Chemotherapy
Part 1. Introduction and outline

Masatoshi Konno

Professor Emeritus, Teikyo University

Abstract

The medical term, "chemotherapy" was coined by Ehrlich. Since then, chemotherapeutic agents have come to represent antimicrobial agents. Mass production of antimicrobial agents through chemical synthesis have brought many benefits to human beings; however, we are realizing that the development of chemotherapeutic agents will also come to an end. It can be said that human beings have only focused on the benefits of chemotherapy and have ignored the risks.
The author was asked to make a special comment on this subject at the annual meeting of the Japanese Society of Chemotherapy in 2015. The following points were covered: 1) Bacterial resistance to antimicrobial agents; 2) Saturation of the development of new antimicrobial agents; 3) Recognition of the negative side of antimicrobial therapy and drug resistance; 4) Positive and negative effects of actions by the Japanese Society of Chemotherapy; 5) Fact of the Society's tendency to only focus on bacterial multi-drug resistance and nosocomial infection control; 6) Catastrophic collapse of pediatric oral antimicrobial agents; and 7) Development of anti-infectious agents that can substitute for antimicrobial agents. We see a reduction in the number of lectures on infectious diseases during medical education and less interest among physicians in infectious diseases. There is also a trend for physicians to outsource tests outside their scope of practice to other laboratories. As a result, it cannot be denied that case reports presented at society meetings tend to rely only on a review of the literature.
Without any interventions, not only will antimicrobial development fade away, but infectious diseases for which there are no effective antimicrobial agents may emerge. For this reason, I think there are many subjects that the members of this society should understand regarding antimicrobial agents and the development of vaccines from now on. This will be a long review, so Part 1 consists of the "Introduction and Outline." Part 2 provides the details of and references for the rationale for "World trend of the development of antimicrobial agents." Part 3 concerns the "Issues involved in infectious diseases due to antimicrobial-resistant microorganisms.

Key word

methicillin-resistant Staphylococcus aureus, penicillin-resistant Streptococcus pneumoniae, β-lactamase negative resistant Haemophilus influenzae, macrolide-resistant Mycoplasma pneumoniae, vaccination

Received

December 16, 2016

Accepted

January 26, 2017

Jpn. J. Chemother. 65 (3): 426-444, 2017