Vol.66 No.6 November 2018
Dissemination of antimicrobial-resistant bacteria based on the One Health concept
Rakuno Gakuen University Center for Veterinary Drug Development, 582 Bunkyodai-Midorimachi, Ebetsu, Hokkaido, Japan
Abstract
Although antimicrobials have been used approximately twice as frequently for food-producing animals as for humans, antimicrobial use for animals has decreased recently. Resistant bacteria originating from food-producing animals has gradually decreased, reflecting the reduced use of antimicrobials for animals. However, antimicrobial-resistant bacteria regarded as important in human medicine are still often detected from animals. It is necessary to pay attention to livestock-associated methicillin-resistant Staphylococcus aureus and plasmid-mediated colistin-resistant Escherichia coli, that are widespread in Europe and USA. On the other hand, the bacteria isolated from the companion animals frequently produce extended-spectrum β -lactamase (ESBL). In addition, potential spread of resistant bacteria from dogs to humans has been suggested. Furthermore, antimicrobials are also detected in low concentrations in the environment, and resistant bacteria in wild animals and waste water. Therefore, resistant bacteria circulate in the ecosystem, and it is important to control resistant bacteria based on the One Health approach according to Japanese Antimicrobial Resistance (AMR) action plan formulated in 2016.
Key word
antimicrobial agents, animal, environment, MRSA, mcr-1
Received
April 23, 2018
Accepted
June 7, 2018
Jpn. J. Chemother. 66 (6): 715-728, 2018
