Vol.70 No.5 September 2022

Sensitivity of multidrug-resistant Gram-negative rods to tazobactam/ceftolozane

Kaori Nagayama^{1, 2)}, Tomohiro Oishi^{2, 3)}, Masaki Ishimatsu^{1, 2)}, Tetsuhide Fujii^{2, 4)}, Satoshi Kaya^{2, 4)} and Daisuke Yoshioka^{2, 3)}

¹⁾Department of Central Clinical Laboratory, Kawasaki Medical School Hospital, 577 Matsushima, Kurashiki, Okayama, Japan
²⁾Department of Infection Control Team, Kawasaki Medical School Hospital
³⁾Department of Clinical Infectious Diseases, Kawasaki Medical School Hospital
⁴⁾Department of Pharmacy, Kawasaki Medical School Hospital

Abstract

We analyzed the minimum inhibitory concentration (MIC) of tazobactam/ceftolozane (TAZ/CTLZ), which was developed as a new antibiotic against multidrug-resistant Gram-negative rods, using MicroScan^® panels.
The susceptibility rate of carbapenemase-producing Enterobacteriaceae (CPE) to TAZ/CTLZ was 0%, but the susceptibility rates of carbapenemase-non-producing Enterobacteriaceae other than CPE, extended spectrum β-lactamase produce Enterobacteriaceae, and multidrug-resistant Pseudomonas aeruginosa (MDRPA) were 94.1%, 87.5%, and 80.0%, respectively. In particular, the susceptibility rate of MDRPA to TAZ/CTLZ was the highest among β-lactam antibiotics.

Key word

tazobactam/ceftolozane, multidrug-resistant Gram-negative rods

Received

May 6, 2022

Accepted

July 8, 2022

Jpn. J. Chemother. 70 (5): 402-407, 2022